NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1
Identifieur interne : 002794 ( Main/Exploration ); précédent : 002793; suivant : 002795NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1
Auteurs : D. Yuen ; R. Leu ; J. Tse ; S. Wang ; L. L. Chen [États-Unis] ; L. Chen [États-Unis]Source :
- Lymphology [ 0024-7766 ] ; 2014.
Abstract
Murine bEnd.3 endothelioma cell line has been widely used in vascular research and here we report the novel finding that bEnd.3 cells express lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR-3). Moreover, these cells express progenitor cell markers of Sca-1 and CD133. Upon stimulation with tumor necrosis factor-alpha (TNF-α), the bEnd.3 cells demonstrate enhanced formation of capillary-type tubes, which express LYVE-1. As the bEnd.3 cell line is derived from murine endothelioma, we further examined human tissues of endothelioma and identified lymphatic vessels in the tumor samples which express both LYVE-1 and podoplanin. Moreover, a significantly higher number of lymphatic vessels were detected in the endothelioma samples compared with normal control. Taken together, this study not only redefines bEnd.3 cells for vascular research, but also indicates a broader category of human diseases that are associated with lymphatics, such as endothelioma.
Url:
PubMed: 25282873
PubMed Central: 4636729
Affiliations:
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Chen</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chen, L" sort="Chen, L" uniqKey="Chen L" first="L." last="Chen">L. Chen</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25282873</idno><idno type="pmc">4636729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636729</idno><idno type="RBID">PMC:4636729</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003262</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003262</idno><idno type="wicri:Area/Pmc/Curation">003261</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003261</idno><idno type="wicri:Area/Pmc/Checkpoint">001971</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001971</idno><idno type="wicri:Area/Ncbi/Merge">006B73</idno><idno type="wicri:Area/Ncbi/Curation">006B73</idno><idno type="wicri:Area/Ncbi/Checkpoint">006B73</idno><idno type="wicri:doubleKey">0024-7766:2014:Yuen D:novel:characterization:of</idno><idno type="wicri:Area/Main/Merge">002798</idno><idno type="wicri:Area/Main/Curation">002794</idno><idno type="wicri:Area/Main/Exploration">002794</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NOVEL CHARACTERIZATION OF bEnd.3 CELLS THAT EXPRESS LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR-1</title><author><name sortKey="Yuen, D" sort="Yuen, D" uniqKey="Yuen D" first="D." last="Yuen">D. Yuen</name></author><author><name sortKey="Leu, R" sort="Leu, R" uniqKey="Leu R" first="R." last="Leu">R. Leu</name></author><author><name sortKey="Tse, J" sort="Tse, J" uniqKey="Tse J" first="J." last="Tse">J. Tse</name></author><author><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S." last="Wang">S. Wang</name></author><author><name sortKey="Chen, L L" sort="Chen, L L" uniqKey="Chen L" first="L. L." last="Chen">L. L. Chen</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology (SW, LLC), Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chen, L" sort="Chen, L" uniqKey="Chen L" first="L." last="Chen">L. Chen</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Eye Disease and Development (DY, RL, JT, LC), Program in Vision Science and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Murine bEnd.3 endothelioma cell line has been widely used in vascular research and here we report the novel finding that bEnd.3 cells express lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and vascular endothelial growth factor receptor-3 (VEGFR-3). Moreover, these cells express progenitor cell markers of Sca-1 and CD133. Upon stimulation with tumor necrosis factor-alpha (TNF-α), the bEnd.3 cells demonstrate enhanced formation of capillary-type tubes, which express LYVE-1. As the bEnd.3 cell line is derived from murine endothelioma, we further examined human tissues of endothelioma and identified lymphatic vessels in the tumor samples which express both LYVE-1 and podoplanin. Moreover, a significantly higher number of lymphatic vessels were detected in the endothelioma samples compared with normal control. Taken together, this study not only redefines bEnd.3 cells for vascular research, but also indicates a broader category of human diseases that are associated with lymphatics, such as endothelioma.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li></region></list><tree><noCountry><name sortKey="Leu, R" sort="Leu, R" uniqKey="Leu R" first="R." last="Leu">R. Leu</name><name sortKey="Tse, J" sort="Tse, J" uniqKey="Tse J" first="J." last="Tse">J. Tse</name><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S." last="Wang">S. Wang</name><name sortKey="Yuen, D" sort="Yuen, D" uniqKey="Yuen D" first="D." last="Yuen">D. Yuen</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Chen, L L" sort="Chen, L L" uniqKey="Chen L" first="L. L." last="Chen">L. L. Chen</name></region><name sortKey="Chen, L" sort="Chen, L" uniqKey="Chen L" first="L." last="Chen">L. 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